continuous-flow synthesis of deuterium-labeled antidiabetic chalcones: studies towards the selective deuteration of the alkynone core
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ID: 185347
2016
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Abstract
Flow chemistry-based syntheses of deuterium-labeled analogs of important antidiabetic chalcones were achieved via highly controlled partial C≡C bond deuteration of the corresponding 1,3-diphenylalkynones. The benefits of a scalable continuous process in combination with on-demand electrolytic D2 gas generation were exploited to suppress undesired over-reactions and to maximize reaction rates simultaneously. The novel deuterium-containing chalcone derivatives may have interesting biological effects and improved metabolic properties as compared with the parent compounds.
| Reference Key |
tvs2016moleculescontinuous-flow
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|---|---|
| Authors | ;Sándor B. Ötvös;Chi-Ting Hsieh;Yang-Chang Wu;Jih-Heng Li;Fang-Rong Chang;Ferenc Fülöp |
| Journal | Journal of ethnopharmacology |
| Year | 2016 |
| DOI |
10.3390/molecules21030318
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| URL | |
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