wingless/wnt signaling in intestinal development, homeostasis, regeneration and tumorigenesis: a drosophila perspective

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ID: 185131
2018
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Abstract
In mammals, the Wnt/β-catenin signal transduction pathway regulates intestinal stem cell maintenance and proliferation, whereas Wnt pathway hyperactivation, resulting primarily from the inactivation of the tumor suppressor Adenomatous polyposis coli (APC), triggers the development of the vast majority of colorectal cancers. The Drosophila adult gut has recently emerged as a powerful model to elucidate the mechanisms by which Wingless/Wnt signaling regulates intestinal development, homeostasis, regeneration, and tumorigenesis. Herein, we review recent insights on the roles of Wnt signaling in Drosophila intestinal physiology and pathology.
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tian2018journalwingless/wnt Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Ai Tian;Hassina Benchabane;Yashi Ahmed
Journal journal of counseling psychology
Year 2018
DOI
10.3390/jdb6020008
URL
http://www.mdpi.com/2221-3759/6/2/8
Keywords
animal model adenomatous polyposis coli (apc)

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