increased ny-eso-1 expression and reduced infiltrating cd3+ t cells in cutaneous melanoma
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ID: 185028
2015
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Abstract
NY-ESO-1 is a cancer-testis antigen aberrantly expressed in melanomas, which may serve as a robust and specific target in immunotherapy. NY-ESO-1 antigen expression, tumor features, and the immune profile of tumor infiltrating lymphocytes were assessed in primary cutaneous melanoma. NY-ESO-1 protein was detected in 20% of invasive melanomas (16/79), rarely in in situ melanoma (1/10) and not in benign nevi (0/20). Marked intratumoral heterogeneity of NY-ESO-1 protein expression was observed. NY-ESO-1 expression was associated with increased primary tumor thickness (P=0.007) and inversely correlated with superficial spreading melanoma (P<0.02). NY-ESO-1 expression was also associated with reduced numbers and density of CD3+ tumor infiltrating lymphocytes (P=0.017). When NY-ESO-1 protein was expressed, CD3+ T cells were less diffusely infiltrating the tumor and were more often arranged in small clusters (P=0.010) or as isolated cells (P=0.002) than in large clusters of more than five lymphocytes. No correlation of NY-ESO-1 expression with gender, age, tumor site, ulceration, lymph node sentinel status, or survival was observed. NY-ESO-1 expression in melanoma was associated with tumor progression, including increased tumor thickness, and with reduced tumor infiltrating lymphocytes.
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| Reference Key |
giavina-bianchi2015journalincreased
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|---|---|
| Authors | ;Mara Giavina-Bianchi;Pedro Giavina-Bianchi;Mirian Nacagami Sotto;Alona Muzikansky;Jorge Kalil;Cyro Festa-Neto;Lyn M. Duncan |
| Journal | journal of photochemistry and photobiology b, biology |
| Year | 2015 |
| DOI |
10.1155/2015/761378
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| URL | |
| Keywords |
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