phytoconstituents with radical scavenging and cytotoxic activities from diospyros shimbaensis
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ID: 184935
2016
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Abstract
As part of our search for natural products having antioxidant and anticancer properties, the phytochemical investigation of Diospyros shimbaensis (Ebenaceae), a plant belonging to a genus widely used in East African traditional medicine, was carried out. From its stem and root barks the new naphthoquinone 8,8′-oxo-biplumbagin (1) was isolated along with the known tetralones trans-isoshinanolone (2) and cis-isoshinanolone (3), and the naphthoquinones plumbagin (4) and 3,3′-biplumbagin (5). Compounds 2, 4, and 5 showed cytotoxicity (IC50 520–82.1 μM) against MDA-MB-231 breast cancer cells. Moderate to low cytotoxicity was observed for the hexane, dichloromethane, and methanol extracts of the root bark (IC50 16.1, 29.7 and > 100 μg/mL, respectively), and for the methanol extract of the stem bark (IC50 59.6 μg/mL). The radical scavenging activity of the isolated constituents (1–5) was evaluated on the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. The applicability of the crude extracts and of the isolated constituents for controlling degenerative diseases is discussed.
| Reference Key |
aronsson2016diseasesphytoconstituents
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|---|---|
| Authors | ;Per Aronsson;Joan J. E. Munissi;Amra Gruhonjic;Paul A. Fitzpatrick;Göran Landberg;Stephen S. Nyandoro;Mate Erdelyi |
| Journal | Technology in society |
| Year | 2016 |
| DOI |
10.3390/diseases4010003
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