noncytotoxic and antitumour-promoting activities of garcinia acid esters from garcinia atroviridis griff. ex t. anders (guttiferae)
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ID: 184760
2012
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Abstract
The in vitro antitumour-promoting, cytotoxic, and antioxidant activities of two ester derivatives of garcinia acid, that is, 2-(butoxycarbonylmethyl)-3-butoxycarbonyl-2-hydroxy-3-propanolide (1) and 1′,1′′-dibutyl methyl hydroxycitrate (2), that had been previously isolated from the fruits of Garcinia atroviridis Griff. ex T. Anders (Guttiferae), were examined. Based on the inhibition of Epstein-Barr virus early antigen (EBV-EA) activation, compound 1 (IC50: 70 μM) showed much higher (8-fold) antitumour-promoting activity than compound 2 (IC50: 560 μM). In addition, both compounds were nontoxic towards CEM-SS (human T-lymphoblastic leukemia) cells (CD50: >100 μM), Raji (human B-lymphoblastoid) cells (CD50: >600 μM), and brine shrimp (LD50: >300 μM). Although the antitumour-promoting activity of compound 1 is moderate compared with the known antitumour promoter genistein, its non-toxicity suggests the potential of compound 1 and related structures as chemopreventive agents. The weak antioxidant activity displayed by both compounds also suggested that the primary antitumour-promoting mechanism of compound 1 did not involve oxidative-stress quenching.
| Reference Key |
mackeen2012evidence-basednoncytotoxic
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|---|---|
| Authors | ;Mukram M. Mackeen;Lim Y. Mooi;Mohidin Amran;Nashriyah Mat;Nordin H. Lajis;Abdul M. Ali |
| Journal | ACS applied materials & interfaces |
| Year | 2012 |
| DOI |
10.1155/2012/829814
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| URL | |
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