effect of kramecyne on the inflammatory response in lipopolysaccharide-stimulated peritoneal macrophages

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ID: 184292
2013
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Abstract
Kramecyne is a new peroxide, it was isolated from Krameria cytisoides, methanol extract, and this plant was mostly found in North and South America. This compound showed potent anti-inflammatory activity; however, the mechanisms by which this compound exerts its anti-inflammatory effect are not well understood. In this study, we examined the effects of kramecyne on inflammatory responses in mouse lipopolysaccharide- (LPS-) induced peritoneal macrophages. Our findings indicate that kramecyne inhibits LPS-induced production of tumor necrosis factor (TNF-α) and interleukin- (IL-) 6. During the inflammatory process, levels of cyclooxygenase- (COX-) 2, nitric oxide synthase (iNOS), and nitric oxide (NO) increased in mouse peritoneal macrophages; however, kramecyne suppressed them significantly. These results provide novel insights into the anti-inflammatory actions and support its potential use in the treatment of inflammatory diseases.
Reference Key
snchez-miranda2013evidence-basedeffect Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;E. Sánchez-Miranda;J. Lemus-Bautista;S. Pérez;J. Pérez-Ramos
Journal ACS applied materials & interfaces
Year 2013
DOI
10.1155/2013/762020
URL
http://dx.doi.org/10.1155/2013/762020
Keywords
Other systems of medicine

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