papillomavirus infectious pathways: a comparison of systems

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2015
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Abstract
The HPV viral lifecycle is tightly linked to the host cell differentiation, causing difficulty in growing virions in culture. A system that bypasses the need for differentiating epithelium has allowed for generation of recombinant particles, such as virus-like particles (VLPs), pseudovirions (PsV), and quasivirions (QV). Much of the research looking at the HPV life cycle, infectivity, and structure has been generated utilizing recombinant particles. While recombinant particles have proven to be invaluable, allowing for a rapid progression of the HPV field, there are some significant differences between recombinant particles and native virions and very few comparative studies using native virions to confirm results are done. This review serves to address the conflicting data in the HPV field regarding native virions and recombinant particles.
Reference Key
biryukov2015virusespapillomavirus Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Jennifer Biryukov;Craig Meyers
Journal International journal of pharmaceutics
Year 2015
DOI
10.3390/v7082823
URL
http://www.mdpi.com/1999-4915/7/8/2823
Keywords
human papillomavirus (hpv) virus quasivirions (qv)microbiology

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