induced marine fungus chondrostereum sp. as a means of producing new sesquiterpenoids chondrosterins i and j by using glycerol as the carbon source

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ID: 184050
2014
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Abstract
Chondrostereum sp., a marine fungus isolated from a soft coral Sarcophyton tortuosum, can yield hirsutane framework sesquiterpenoids. However, the metabolites profiles vary dramatically with the composition change of the culture media. This fungus was cultured in a liquid medium containing glycerol as the carbon source, and two new metabolites, chondrosterins I and J (1 and 2), were obtained. Their structures were elucidated primarily based on MS, NMR and X-ray single-crystal diffraction data. By comparison with the known hirsutane sesquiterpenoids, chondrosterins I and J have unique structural features, including a methyl was migrated from C-2 to C-6, and the methyl at C-3 was carboxylated. Compound 2 exhibited potent cytotoxic activities against the cancer cell lines CNE-1 and CNE-2 with the IC50 values of 1.32 and 0.56 μM.
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li2014marineinduced Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Hou-Jin Li, Wen-Han Jiang, Wan-Ling Liang, Jia-Xin Huang, Yu-Fei Mo, Yan-Qing Ding, Chi-Keung Lam, Xiao-Jun Qian, Xiao-Feng Zhu, Wen-Jian Lan
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Journal jixie gongcheng xuebao/journal of mechanical engineering
Year 2014
DOI
10.3390/md12010167
URL
http://www.mdpi.com/1660-3397/12/1/167
Keywords
sesquiterpenoids marine fungus

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