induced marine fungus chondrostereum sp. as a means of producing new sesquiterpenoids chondrosterins i and j by using glycerol as the carbon source
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ID: 184050
2014
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Abstract
Chondrostereum sp., a marine fungus isolated from a soft coral Sarcophyton tortuosum, can yield hirsutane framework sesquiterpenoids. However, the metabolites profiles vary dramatically with the composition change of the culture media. This fungus was cultured in a liquid medium containing glycerol as the carbon source, and two new metabolites, chondrosterins I and J (1 and 2), were obtained. Their structures were elucidated primarily based on MS, NMR and X-ray single-crystal diffraction data. By comparison with the known hirsutane sesquiterpenoids, chondrosterins I and J have unique structural features, including a methyl was migrated from C-2 to C-6, and the methyl at C-3 was carboxylated. Compound 2 exhibited potent cytotoxic activities against the cancer cell lines CNE-1 and CNE-2 with the IC50 values of 1.32 and 0.56 μM.
| Reference Key |
li2014marineinduced
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| Authors | ;Hou-Jin Li;Wen-Han Jiang;Wan-Ling Liang;Jia-Xin Huang;Yu-Fei Mo;Yan-Qing Ding;Chi-Keung Lam;Xiao-Jun Qian;Xiao-Feng Zhu;Wen-Jian Lan |
| Journal | jixie gongcheng xuebao/journal of mechanical engineering |
| Year | 2014 |
| DOI |
10.3390/md12010167
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| URL | |
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