connexins in the central nervous system: physiological traits and neuroprotective targets

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ID: 183994
2017
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Abstract
Cell-to-cell interaction and cell-to-extracellular environment communication are emerging as new therapeutic targets in neurodegenerative disorders. Dynamic expression of connexins leads to distinctive hemichannels and gap junctions, characterized by cell-specific conduction, exchange of stimuli or metabolites, and particular channel functions. Herein, we briefly reviewed classical physiological traits and functions of connexins, hemichannels, and gap junctions, in order to discuss the controversial role of these proteins and their mediated interactions during neuroprotection, with a particular focus on Cx43-based channels. We pointed out the contribution of connexins in neural cells populations during neurodegenerative processes to explore potential neuroprotective therapeutic applications.
Reference Key
vicario2017frontiersconnexins Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Nunzio Vicario;Agata Zappalà;Giovanna Calabrese;Rosario Gulino;Carmela Parenti;Massimo Gulisano;Massimo Gulisano;Rosalba Parenti
Journal Journal of clinical and experimental dentistry
Year 2017
DOI
10.3389/fphys.2017.01060
URL
http://journal.frontiersin.org/article/10.3389/fphys.2017.01060/full
Keywords
neurodegeneration gap junction connexin hemichannel

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