research progress on the prevalence and pathogen of dry eye syndrome after corneal refractive surgery

Because of the rapid improving of corneal refractive surgery with laser, its characteristics such as safety, stability, availability and predictability have already been proved by clinical practice. Laser in situ keratomileusis(LASIK), epipolis laser in situ keratomileusis(Epi-LASIK), femtosecond laser in situ keratomileusis(FS-LASIK)and small incision lenticule extraction(SMILE)are the main operational methods. SMILE has gradually been being accepted by young and middle-aged with its minimal invasive and little post-surgery complications. Dry eye syndrome is one of the most common complications that may affect the visual effect of the surgery. Specialists and patients have paid more attention to dry eye disease after corneal refractive surgery. According to clinical and experimental researches, the basic condition of ocular surface before surgery, the application of drugs in or after the surgery, the type of refractive surgery that operator choose, as well as the damage and reinnervation of corneal nerve all play important roles in post-surgery dry eye. This article reviews the pathogen of dry eye disease after surgery and the prevalence of dry eye after surgery.