alkaloids and triterpene from almeidea coerulea (nees and mart.) a. st.-hil. and anti-leishmanial activity
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ID: 183891
2011
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Abstract
The dichloromethane extract of Almeidea coerulea stems yielded the (11-hydroxyrutaecarpine alkaloid reported for the first time from this species) and the triterpene (28-hydroxy-28, 29-dihydrolupeol). The dictamine, skimianine, sitosterol and stigmasterol were also isolated from methanol extract. Extracellular forms of Leishmania amazonensis (promastigotes) was tested with dichloromethane extract and 28-hydroxy-28, 29-dihydrolupeol with showed anti-leishmanial activity above 0.1 mg/mL and 75µg/mL (inhibited 50% promastigote growth), respectively.
| Reference Key |
cortez2011brazilianalkaloids
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|---|---|
| Authors | ;Lucia Elaine Ranieri Cortez;Izabel Cristina Piloto Ferreira;Valdrinez Campana Lonardoni;Antonio Gilberto Ferreira;Paulo Cesar Vieira;Maria Fátima das Graças Fernandes da Silva;João Batista Fernandes;Diógenes Aparicio Garcia Cortez |
| Journal | current drug delivery |
| Year | 2011 |
| DOI |
10.1590/S1516-89132011000100008
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| URL | |
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