t follicular helper and th2 cells in allergic responses

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ID: 183637
2017
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Abstract
IL-4 is a cytokine commonly secreted by TH2 and follicular helper T (TFH) cells after antigenic sensitization. TH2 cells have been thought to be the major contributor of B cell help as a source of IL-4 responsible for class switch recombination to Immunoglobulin G1 (IgG1) and Immunoglobulin E (IgE). Importantly, there are some differences in transcriptional regulation between these two T cell subsets. The IL-4 production by TH2 and TFH cells is distinctively regulated by two pathways, GATA-3-mediated Il4-HS2 enhancer and Notch mediated Il4-CNS-2 enhancer. IgE and IgG1 antibody responses are mainly controlled by IL-4-secreting TFH cells, but not by TH2 cells. In this review, we discuss the role of TH2 and TFH cells in IgE production and allergic responses.
Reference Key
kubo2017allergologyt Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Masato Kubo
Journal current drug discovery technologies
Year 2017
DOI
10.1016/j.alit.2017.04.006
URL
http://www.sciencedirect.com/science/article/pii/S1323893017300473
Keywords
th2 il-4 immunoglobulin e (ige) allergy

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