value of a new inflammatory parameter in malignant pleural mesothelioma prognosis

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ID: 183506
2013
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Abstract
Malignant Pleural Mesothelioma (MPM) generallyassociated with asbestos exposure is a tumor withpoor prognosis. Modified Glasgow Prognostic Score(GPS) which may be a prognostic parameter in patientswith MPM is a designed based score including increasedC-reactive protein (CRP) levels and decreased albumin.In this study we aimed to investigate the effect of GPSscore on the prognosis of MPM and the role of other potentialfactors.Methods: In this retrospective planned study 140 histologicaldiagnosed MPM patients were included.Results: Mean age of 140 MPM patients were 52.92years (83 male and 57 female). A total of 91 patients hadenvironmental asbestos exposure and exposure timewas the 31 years. Symptoms of the patients started approximately4.8 months before the application. The mostfrequently seen symptoms were in 125 patients dyspnea,in 94 patients chest pain and in 22 patients weight loss.GPS score of the patients were as follows; 64 patientstwo, 14 patients one, 22 patients zero. Of the patients,112 died and 28 were alive. Mean survival time was 14months. Patients with GPS score 2 lived for 10 months,GPS score 1 lived for 15 and GPS score 0 lived for 18months. This difference was statistically significant. Furthermore,the male sex and age older than 65 years werefound as poor prognostic parameters on the survival.Conclusion: A simple and inexpensive parameter able tobe used to estimate the prognosis of MPM patients couldnot be developed .GPS score increases in inflammatoryconditions. GPS is a simple and inexpensive parameterthat can be used for detecting the severity of patients withMPM.Key words: Modified Glasgow Prognostic Score, MalignantPleural Mesothelioma, Prognosis
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abakay2013diclevalue Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Özlem Abakay;Abdullah Çetin Tanrıkulu;Cengizhan Sezgi;Abdurrahman Abakay;Hadice Şen;Halide Kaya;Mahşuk Taylan
Journal journal of sulfur chemistry
Year 2013
DOI
10.5798/diclemedj.0921.2013.02.0262
URL
http://www.diclemedj.org/upload/sayi/27/Dicle%20Med%20J-01671.pdf
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