yangxue qingnao wan and silibinin capsules, the two chinese medicines, attenuate cognitive impairment in aged ldlr (+/-) golden syrian hamsters involving protection of blood brain barrier

Clicks: 347
ID: 183018
2018
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #76 of 461 articles by views in Journal of clinical and experimental dentistry

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 461 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
The purpose of the study was to explore the effect and the underlying mechanism of YangXue QingNao Wan (YXQNW) and Silibinin Capsules (SC), the two Chinese medicines, on cognitive impairment in older people with familial hyperlipidaemia. Fourteen month-old female LDLR (+/-) golden Syrian hamsters were used with their wild type as control. YXQNW (0.5 g/kg/day), SC (0.1 g/kg/day), or YXQNW (0.5 g/kg/day) + SC (0.1 g/kg/day) were administrated orally for 30 days. To assess the effects of the two drugs on plasma lipid content and cognitive ability, plasma TC, TG, LDL-C, and HDL-C were measured, and Y maze task was carried out both before and after administration. After administering of the drugs for 30 days, to evaluate the effect of the two drugs on disturbed blood flow caused by hyperlipidemia, the cerebral blood flow (CBF) was measured. To assess blood–brain barrier integrity, albumin leakage in middle cerebral artery (MCA) area was determined. To evaluate the effect of the drugs on impaired microvessels, the number and morphology of microvessels were assessed in hippocampus area. To further evaluate the ultrastructure of microvessels in hippocampus, transmission electron microscopy (TEM) and scanning electron microscopy (SEM) were carried out. To assess the profiles of claudin-5 and occludin in hippocampus, we performed immunofluorescence. Finally, to assess the expression of claudin-5, JAM-1, occludin and ZO-1 in hippocampus, western blot was carried out. The results showed that YXQNW, SC, and YXQNW + SC improved cognitive impairment of aged LDLR (+/-) golden Syrian hamsters without lowering plasma TC and LDL-C. YXQNW, SC, and YXQNW + SC attenuated albumin leakage in MCA area and neuronal damage in hippocampus, concomitant with an increase in CBF, a decrease of perivascular edema and an up-regulated expression of claudin-5, occludin and ZO-1. In conclusion, YXQNW, SC, and YXQNW + SC are able to improve cognitive ability in aged LDLR (+/-) golden Syrian hamsters via mechanisms involving maintaining blood–brain barrier integrity. These findings provide evidence suggesting YXQNW or SC as a potential regime to counteract the cognitive impairment caused by familial hypercholesterolemia.
Reference Key
gu2018frontiersyangxue Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;You-Yu Gu;You-Yu Gu;You-Yu Gu;You-Yu Gu;Ping Huang;Ping Huang;Ping Huang;Ping Huang;Quan Li;Quan Li;Quan Li;Quan Li;Yu-Ying Liu;Yu-Ying Liu;Yu-Ying Liu;Yu-Ying Liu;George Liu;Yu-Hui Wang;Ming Yi;Li Yan;Li Yan;Li Yan;Li Yan;Xiao-Hong Wei;Xiao-Hong Wei;Xiao-Hong Wei;Xiao-Hong Wei;Lei Yang;Bai-He Hu;Bai-He Hu;Bai-He Hu;Bai-He Hu;Xin-Rong Zhao;Xin-Rong Zhao;Xin-Rong Zhao;Xin-Rong Zhao;Xin Chang;Xin Chang;Xin Chang;Xin Chang;Kai Sun;Kai Sun;Kai Sun;Kai Sun;Chun-Shui Pan;Chun-Shui Pan;Chun-Shui Pan;Chun-Shui Pan;Yuan-Chen Cui;Yuan-Chen Cui;Yuan-Chen Cui;Yuan-Chen Cui;Qing-Fang Chen;Qing-Fang Chen;Qing-Fang Chen;Qing-Fang Chen;Chuan-She Wang;Chuan-She Wang;Chuan-She Wang;Chuan-She Wang;Chuan-She Wang;Jing-Yu Fan;Jing-Yu Fan;Jing-Yu Fan;Jing-Yu Fan;Zhi-Zhong Ma;Jing-Yan Han;Jing-Yan Han;Jing-Yan Han;Jing-Yan Han;Jing-Yan Han
Journal Journal of clinical and experimental dentistry
Year 2018
DOI
10.3389/fphys.2018.00658
URL
https://www.frontiersin.org/article/10.3389/fphys.2018.00658/full
Keywords
familial hypercholesterolemia cognitive

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.