mechanisms of adaptive immunity to porcine reproductive and respiratory syndrome virus

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ID: 183012
2017
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Abstract
The adaptive immune response is necessary for the development of protective immunity against infectious diseases. Porcine reproductive and respiratory syndrome virus (PRRSV), a genetically heterogeneous and rapidly evolving RNA virus, is the most burdensome pathogen of swine health and wellbeing worldwide. Viral infection induces antigen-specific immunity that ultimately clears the infection. However, the resulting immune memory, induced by virulent or attenuated vaccine viruses, is inconsistently protective against diverse viral strains. The immunological mechanisms by which primary and memory protection are generated and used are not well understood. Here, we summarize current knowledge regarding cellular and humoral components of the adaptive immune response to PRRSV infection that mediate primary and memory immune protection against viruses.
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rahe2017virusesmechanisms Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Michael C. Rahe;Michael P. Murtaugh
Journal International journal of pharmaceutics
Year 2017
DOI
10.3390/v9060148
URL
http://www.mdpi.com/1999-4915/9/6/148
Keywords
memory t cell neutralizing antibody nk cell porcine b cell prrsv

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