regulation of electrolyte transport with il-1β in rabbit distal colon
Clicks: 126
ID: 182986
1995
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Abstract
Interletrkin-1β levels are elevated in inflammatory bowel disease. In this study the mechanism by which interleukin-1β affects electrolyte transport in the rabbit distal colon, was investigated. Interleukin-1β caused a delayed increase in short-circuit current (Isc) which was attributed to protein synthesis since the effect was inhibited by cycloheximide. The interleukin-1β induced increase in Isc was not affected by amiloride treatment but was completely inhibited by bumetanide or in chloride-free buffer and by indomethacin. Prostaglandin E2 levels increased in tissue treated with interleukin-1β, but this increase was reversed by cycloheximide. These data suggest that interleukin-1β causes its effect via a yet to be identified second messenger, by increasing chloride secretion through a prostaglandin E2 mediated mechanism.
| Reference Key |
homaidan1995mediatorsregulation
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|---|---|
| Authors | ;F. R. Homaidan;H. Desai;L. Zhao;G. Broutman;R. Burakoff |
| Journal | polyhedron |
| Year | 1995 |
| DOI |
10.1155/S0962935195000111
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| URL | |
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