erythrogram, oxidative stress and mineral interaction in naturally infected lambs supplemented with different forms of oral iron
eritrograma, estresse oxidativo e interação mineral em cordeiros naturalmente infectados por parasitas gastrintestinais suplementados com diferentes formas de ferro oral

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ID: 182389
2012
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Abstract
The present study aimed to assess the oxidative profile, erythrogram and mineral interaction in lambs with anemia due to worm infection supplemented with different forms of oral iron. It was used 27 lambs, 6 to 8 month old, naturally infected by Haemonchus contortus, which showed packed cell volume between 16 and 18%. The animals were divided in three groups: Control Group (GC) n=9, Ferrous Sulphate Group (G2) n=9 and Ferric Sulphate Group (G3) n=9. The animals of G2 received 1 g of ferrous sulphate (Fe+2) orally daily, equivalent to 200 milligram of iron, the animals of G3 received 1 g of ferric sulphate (Fe+3) orally daily, or equivalent to 200 milligram of iron, whereas the GC received no treatment. The samples were taked on day 0, 7, 14, 21 and 28 of the experiment, and during four days two animals of each group were kept in metabolic cages to measure the faecal minerals excretion. There was no difference among the groups about serum iron values and parameters of red blood cells. The serum copper and zinc values were lower in the G2 and G3 on days 21 and 28 of the experiment, whereas the faecal copper, iron and zinc excretion was higher in the same groups. The superoxide dismutase (SOD) levels were lower in the G2 and G3 on day 28 whereas the levels of non-protein thiol groups (NPTH) showed a decrease on days 21 and 28. In relation to reactive species thio-barbituric acid (TBARS), there was an increase on day 28 in the G2 and G3. Based on these results, it was concluded that the oral supplementation with 200 mg of iron, irrespective of its form, ferrous or ferric, does not increase the erythrocyte response in lambs. As well as, it has antagonist action on copper and zinc, reducing its serum concentrations and increasing the faecal excretion of these minerals. Moreover, the decrease of the serum copper and zinc concentrations causes a decrease in activity of superoxide dismutase, causing an oxidative stress situation.

O presente estudo teve por objetivo avaliar o perfil oxidativo, eritrograma e interação mineral em cordeiros com anemia verminótica suplementados com diferentes formas de ferro oral. Foram utilizados 27 cordeiros com idade entre 6 e 8 meses naturalmente infectados por Haemonchus contortus, apresentando volume globular entre 16 e 18%. Os animais foram divididos em três grupos; Grupo controle (GC) n= 9, Grupo Sulfato ferroso (G2) n= 9 e Grupo Sulfato férrico (G3) n= 9. Os animais do G2 receberam via oral, diariamente 1 grama de sulfato ferroso (Fe+2), equivalente a 200 miligramas de ferro, os animais do G3 receberam 1 grama de sulfato férrico (Fe+3) via oral, diariamente, equivalente a 200 miligramas de ferro, os animais do GC não receberam tratamento. As coletas foram realizadas nos dias 0, 7, 14, 21 e 28 do experimento, e durante quatro dias dois animais de cada grupo foram mantidos em gaiolas metabólicas para mensuração da excreção fecal de minerais. Não houve diferença entre os grupos nos valores de ferro sérico e parâmetros de eritrócitos do sangue. Os valores de cobre e zinco sérico foram inferiores nos G2 e G3 nos dias 21 e 28 do experimento, enquanto que a excreção fecal de cobre, ferro e zinco foram superiores nesses mesmos grupos. Os teores da superoxido desmutase (SOD) foram inferiores nos G2 e G3 no dia 28 enquanto que os teores dos grupos tióis protéicos (NPTH) foram menores nos G2 e G3 nos dias 21 e 28. Os valores de espécies reativas ao ácido tio-barbitúrico (TBARS) foram maiores no dia 28 nos G2 e G3. A suplementação de 200mg de ferro, independente da sua forma, ferrosa ou férrica, não aumenta a resposta eritrocitária em cordeiros com anemia verminótica. Esses compostos possuem ação antagonista sobre cobre e zinco, diminuindo as concentrações séricas desses minerais e aumentando excreção fecal dos mesmos. Em decorrência da diminuição das concentrações séricas de cobre e zinco houve uma diminuição da atividade da superóxido dismutase causando estresse oxidativo

Reference Key
leal2012semina:erythrogram, Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Marta Lizandra Rêgo Leal;Paula Rocha Sampaio Nicolodi;Diego Zeni;Emmanuel Veiga Camargo;Ricardo Xavier Rocha;Marcelo Silva Cecim
Journal frontiers in neuroendocrinology
Year 2012
DOI
10.5433/1679-0359.2012v33n2p723
URL
http://www.uel.br/revistas/uel/index.php/semagrarias/article/view/7518
Keywords Keywords not found

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