2-(5-chlorobenzo[d]thiazol-2-ylimino)thiazolidin-4-one derivatives as an antimicrobial agent

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2017
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Abstract
A series of 2-(5-chlorobenzo[d]thiazol-2-ylimino)-5-((3-(p-substituted phenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)thiazolidin-4-ones (3a–h) were prepared from 2-(5-chlorobenzo[d]thiazol-2-ylimino)thiazolidin-4-one (1) and 1-phenyl-3-(p-substituted phenyl)-1H-pyrazole-4-carbaldehyde (2a–h). All compounds were characterized using elemental analytical (C, H, and N) and spectral (FT-IR, 1H NMR, 13C NMR and GC–MS) data. These compounds were screened for their antibacterial, antifungal and antimycobacterial activities. Antimicrobial activity was evaluated against the bacterial strains e.g., Eschericha coli (MTCC 443), Pseudomonas aeruginosa (MTCC 1688), Staphylococcus aureus (MTCC 96), Streptococcus pyogenes (MTCC 442), H37Rv strain of Mycobacterium tuberculosis, and the antifungal activity was observed against strains e.g., Candida albicans (MTCC 227), Aspergillus niger (MTCC 282) and Aspergillus clavatus (MTCC 1323). All the synthesized compounds were found to possess moderate to excellent activity against selected strains.
Reference Key
bbhatt2017arabian2-(5-chlorobenzo[d]thiazol-2-ylimino)thiazolidin-4-one Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;H. B′Bhatt;S. Sharma
Journal Behavioural brain research
Year 2017
DOI
10.1016/j.arabjc.2012.10.015
URL
http://www.sciencedirect.com/science/article/pii/S1878535212002444
Keywords
Antifungal Activity antibacterial activity antimycobacterial activity 1-phenyl-3-(p-substituted phenyl)-1h-pyrazole-4-carbaldehydechemistry

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