trace elements during primordial plexiform network formation in human cerebral organoids

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ID: 182092
2017
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Abstract
Systematic studies of micronutrients during brain formation are hindered by restrictions to animal models and adult post-mortem tissues. Recently, advances in stem cell biology have enabled recapitulation of the early stages of human telencephalon development in vitro. In the present work, we analyzed cerebral organoids derived from human pluripotent stem cells by synchrotron radiation X-ray fluorescence in order to measure biologically valuable micronutrients incorporated and distributed into the exogenously developing brain. Our findings indicate that elemental inclusion in organoids is consistent with human brain tissue and involves P, S, K, Ca, Fe and Zn. Occurrence of different concentration gradients also suggests active regulation of elemental transmembrane transport. Finally, the analysis of pairs of elements shows interesting elemental interaction patterns that change from 30 to 45 days of development, suggesting short- or long-term associations, such as storage in similar compartments or relevance for time-dependent biological processes. These findings shed light on which trace elements are important during human brain development and will support studies aimed to unravel the consequences of disrupted metal homeostasis for neurodevelopmental diseases, including those manifested in adulthood.
Reference Key
sartore2017peerjtrace Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Rafaela C. Sartore;Simone C. Cardoso;Yury V.M. Lages;Julia M. Paraguassu;Mariana P. Stelling;Rodrigo F. Madeiro da Costa;Marilia Z. Guimaraes;Carlos A. Pérez;Stevens K. Rehen
Journal pediatrics
Year 2017
DOI
10.7717/peerj.2927
URL
https://peerj.com/articles/2927/
Keywords
development neurogenesis trace elements

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