Major subpopulations of in sub-Saharan Africa.

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ID: 18190
2019
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Abstract
Understanding genomic variation and population structure of across Africa is necessary to sustain progress toward malaria elimination. Genome clustering of 2263 isolates from 24 malaria-endemic settings in 15 African countries identified major western, central, and eastern ancestries, plus a highly divergent Ethiopian population. Ancestry aligned to these regional blocs, overlapping with both the parasite's origin and with historical human migration. The parasite populations are interbred and shared genomic haplotypes, especially across drug resistance loci, which showed the strongest recent identity-by-descent between populations. A recent signature of selection on chromosome 12 with candidate resistance loci against artemisinin derivatives was evident in Ghana and Malawi. Such selection and the emerging substructure may affect treatment-based intervention strategies against malaria.
Reference Key
amambuangwa2019majorscience Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Amambua-Ngwa, Alfred;Amenga-Etego, Lucas;Kamau, Edwin;Amato, Roberto;Ghansah, Anita;Golassa, Lemu;Randrianarivelojosia, Milijaona;Ishengoma, Deus;Apinjoh, Tobias;Maïga-Ascofaré, Oumou;Andagalu, Ben;Yavo, William;Bouyou-Akotet, Marielle;Kolapo, Oyebola;Mane, Karim;Worwui, Archibald;Jeffries, David;Simpson, Vikki;D'Alessandro, Umberto;Kwiatkowski, Dominic;Djimde, Abdoulaye A;
Journal Science
Year 2019
DOI
10.1126/science.aav5427
URL
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