contralateral suppression of dpoaes in mice after ouabain treatment

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ID: 181870
2018
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Abstract
Medial olivocochlear (MOC) efferent feedback is suggested to protect the ear from acoustic injury and to increase its ability to discriminate sounds against a noisy background. We investigated whether type II spiral ganglion neurons participate in the contralateral suppression of the MOC reflex. The application of ouabain to the round window of the mouse cochlea selectively induced the apoptosis of the type I spiral ganglion neurons, left the peripherin-immunopositive type II spiral ganglion neurons intact, and did not affect outer hairs, as evidenced by the maintenance of the distorted product otoacoustic emissions (DPOAEs). With the ouabain treatment, the threshold of the auditory brainstem response increased significantly and the amplitude of wave I decreased significantly in the ouabain-treated ears, consistent with the loss of type I neurons. Contralateral suppression was measured as reduction in the amplitude of the 2f1−f2 DPOAEs when noise was presented to the opposite ear. Despite the loss of all the type I spiral ganglion neurons, virtually, the amplitude of the contralateral suppression was not significantly different from the control when the suppressor noise was delivered to the treated cochlea. These results are consistent with the type II spiral ganglion neurons providing the sensory input driving contralateral suppression of the MOC reflex.
Reference Key
li2018neuralcontralateral Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Jieying Li;Yan Chen;Shan Zeng;Chuijin Lai;Yanping Zhang;Liting Zhang;Yuxuan Shi;Tianyu Zhang;Huawei Li;Peidong Dai
Journal tetrahedron
Year 2018
DOI
10.1155/2018/6890613
URL
http://dx.doi.org/10.1155/2018/6890613
Keywords
neurosciences neuropsychiatry biological psychiatry

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