serum cystatin c – a new marker of glomerular filtration rate
Article Quality & Performance Metrics
Readership in this journal
PopularRanked #77 of 231 articles by views in planta medica
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 231 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
Abstract
Background. Estimation of the glomerular filtration rate is an essential part of the evaluation of patients with renal disease. A standard for glomerular filtration rate assessment is CrEDTA clearance. Serum creatinine is the most commonly used marker to estimate the glomerular filtration rate, but it is often not enough accurate. Recently serum cystatin C has been proposed as a new endogenous marker of glomerular filtration rate.
Patients and methods. A total of 231 patients (100 woman and 131 men), who performed CrEDTA clearance in previous 17 months, were enrolled in our study. In each patient serum creatinine and serum cystatin C were also determined. Average age of our patients was 55 years (from 7 to 85 years).
Results. Average CrEDTA clearance was 54.4 ml/min/1.73 m2 (from 2 to 186 ml/min/1.73 m2). Average serum creatinine concentration was 270.2 µmol/l (from 64 to 915 µmol/l) and average serum cystatin C concentration was 2.53 mg/l (from 0.59 to 6.99 mg/l). The correlations between CrEDTA clearance, serum creatinine and serum cystatin C were statistically significant. The correlation between CrEDTA clearance and serum cystatin C was better than correlation between CrEDTA clearance and serum creatinine.
Conclusions. CrEDTA clearance, serum creatinine and serum cystatin C are comparable markers of renal function. Based on our study, serum cystatin C is a more reliable measure of glomerular filtration rate than serum creatinine.
| Reference Key |
hojs2004zdravnikiserum
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;Radovan Hojs;Barbara Antolinc;Maksimiljan Gorenjak;Ludvik Puklavec |
| Journal | planta medica |
| Year | 2004 |
| DOI |
DOI not found
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.