specific and cross-reactive immune response against mycobacterium tuberculosis antigens in mice immunized with proteoliposomes from mycobacterium bovis bcg
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2017
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Abstract
Objective: To characterize the immunogenicity and the induction of cross-reactive responses against Mycobacterium tuberculosis (M. tuberculosis) of a proteoliposome (PL) from Mycobacterium bovis Bacillus Calmette–Guérin (BCG) with and without alum hydroxide (AL) as adjuvant (PLBCG-AL and PLBCG, respectively) in BALB/c mice.
Methods: BALB/c mice were inoculated with phosphate buffer solution, BCG, PLBCG and PLBCG-AL. The humoral immunogenicity was determined by ELISA [immunoglobulin G (IgG), IgG1 and IgG2a] and the cellular immunogenicity was evaluated in vivo by delayed type hypersensitivity. The humoral cross-reactive response against M. tuberculosis was determined by Western blot.
Results: Sera from animals immunized with PLBCG-AL and PLBCG showed significant increase in specific total IgG and IgG1 antibodies and the presence of cross-reactive antibodies against M. tuberculosis antigens, which were more intense with the use of alum as adjuvant. Mice immunized with PLBCG and PLBCG-AL also showed a specific cellular response in vivo.
Conclusions: The cellular and humoral immunogenicity of PLBCG and the capacity to induce cross-reactive responses against M. tuberculosis is in agreement with the protective capacity previously demonstrated by this vaccine candidate and supports the continuation of its evaluation in further stages.
| Reference Key |
alvarez2017asianspecific
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| Authors | ;Nadine Alvarez;Daymí Serpa;Ramlah Kadir;Yanely Tirado;Reinier Borrero;Sonsire Fernández;Rubén Cabrera;Yolanda Valdes;Caridad Zayas;Reinaldo Acevedo;Luis Izquierdo;María Elena Sarmiento;Mohd-Nor Norazmi;José Luis Pérez;Armando Acosta |
| Journal | Organic letters |
| Year | 2017 |
| DOI |
10.1016/j.apjtb.2016.12.013
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| URL | |
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