self-tuning insulin adjustment algorithm for type 1 diabetic patients based on multi-doses regime
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ID: 181602
2005
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Abstract
A self-tuning algorithm is presented for on-line insulin dosage adjustment in type 1 diabetic patients (chronic stage). The algorithm suggested does not need information of the patient insulin–glucose dynamics (model-free). Three doses are programmed daily, where a combination of two types of insulin: rapid/short and intermediate/long acting is injected into the patient through a subcutaneous route. The doses adaptation is performed by reducing the error in the blood glucose level from euglycemics. In this way, a total of five doses are tuned per day: three rapid/short and two intermediate/long, where there is large penalty to avoid hypoglycemic scenarios. Closed-loop simulation results are illustrated using a detailed nonlinear model of the subcutaneous insulin–glucose dynamics in a type 1 diabetic patient with meal intake.
| Reference Key |
campos-delgado2005appliedself-tuning
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|---|---|
| Authors | ;D. U. Campos-Delgado;R. Femat;M. Hernández-Ordoñez;A. Gordillo-Moscoso |
| Journal | water-rock interaction - proceedings of the 13th international conference on water-rock interaction, wri-13 |
| Year | 2005 |
| DOI |
10.1533/abbi.2004.0031
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| URL | |
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