zscan4 is activated after telomere shortening in mouse embryonic stem cells

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ID: 181335
2016
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Abstract
ZSCAN4 is a DNA-binding protein that functions for telomere elongation and genomic stability. In vivo, it is specifically expressed at the two-cell stage during mouse development. In vitro, it is transiently expressed in mouse embryonic stem cells (ESCs), only in 5% of the population at one time. Here we attempted to elucidate when, under what circumstances, Zscan4 is activated in ESCs. Using live cell imaging, we monitored the activity of Zscan4 together with the pluripotency marker Rex1. The lengths of the cell cycles in ESCs were diverse. Longer cell cycles were accompanied by shorter telomeres and higher activation of Zscan4. Since activation of Zscan4 is involved in telomere elongation, we speculate that the extended cell cycles accompanied by Zscan4 activation reflect the time for telomere recovery. Rex1 and Zscan4 did not show any correlation. Taken together, we propose that Zscan4 is activated to recover shortened telomeres during extended cell cycles, irrespective of the pluripotent status.
Reference Key
nakai-futatsugi2016stemzscan4 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Yoko Nakai-Futatsugi;Hitoshi Niwa
Journal nature reviews gastroenterology & hepatology
Year 2016
DOI
10.1016/j.stemcr.2016.02.010
URL
http://www.sciencedirect.com/science/article/pii/S2213671116000618
Keywords
medicine (general)biology (general)

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