maturation and migration of murine cd4 single positive thymocytes and thymic emigrants

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ID: 181118
2014
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Abstract
T lymphopoiesis in the thymus was thought to be completed once they reach the single positive (SP) stage, when they are “fully mature” and wait to be exported at random or follow a “first in-first out” manner. Recently, accumulating evidence has revealed that newly generated SP thymocytes undergo further maturation in the thymic medulla before they follow a tightly regulated emigrating process to become recent thymic emigrants (RTEs). RTEs in the periphery then experience a post-thymic maturation and peripheral tolerance and eventually become licensed as mature naïve T cells. This review summarizes the recent progress in the late stage T cell development in and outside of the thymus. The regulation of this developmental process is also discussed.
Reference Key
xu2014computationalmaturation Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Xi Xu;Qing Ge
Journal ceramics international
Year 2014
DOI
10.5936/csbj.201403003
URL
http://www.sciencedirect.com/science/article/pii/S2001037014600039
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