a histomorphometric study of the effect of doxycycline and erythromycin on bone formation in dental alveolar socket of rat
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2015
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Abstract
Background: The aim of the present study was to evaluate whether subantimicrobial doses of doxycycline (DOX) and erythromycin (EM) used for the treatment of peri-implant osteolysis due to their anti-osteoclastogenesis can interfere with the osseous wound healing process in rat alveolar socket.
Materials and Methods: Forty-five male Wistar rats had their first maxillary right molar extracted and were divided into three groups. DOX and EM at the doses of 5 mg/kg/day orally (p.o.) and 2 mg/kg/day intraperitoneally (i.p.) were administered respectively to two separate groups for 7 days after operation. In the control group the animals received normal saline (5 ml/kg). Five rats were sacrificed at 7, 14 and 21 days post-extraction in each study group. A histomorphometric analysis was used to evaluate new bone formation inside the alveolar socket. Significant level was set at 0.05.
Results: The findings showed that the percentage of new bone formation (NBF) enhanced significantly on days 7 and 14. There was no significant difference in the NBF between DOX and EM groups.
Conclusion: Short-term treatment with both DOX and EM enhanced new bone formation without any advances in favor of each drug.
| Reference Key |
shahabooei2015advanceda
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| Authors | ;Mohammad Shahabooei;Sayed Mohammad Razavi;Mohsen Minaiyan;Reza Birang;Parichehr Behfarnia;Jaber Yaghini;Narges Naghsh;Parichehr Ghalayani;Samira Hajisadeghi |
| Journal | microbiological research |
| Year | 2015 |
| DOI |
10.4103/2277-9175.153895
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