sporulosol, a new ketal from the fungus paraconiothyrium sporulosum
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ID: 180821
2018
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Abstract
Sporulosol (1), a new ketal, together with four known compounds, has been isolated from the liquid fermentation cultures of a wetland-soil-derived fungus, Paraconiothyrium sporulosum. Its structure was elucidated primarily by NMR experiments, and was further confirmed by X-ray crystallography. Sporulosol was obtained as a racemic mixture and the resolved two enantiomers racemized immediately after chiral separation. Sporulosol appears to be the first ketal derived from a 6H-benzo[c]chromen-6-one and a benzofuranone unit. The compound showed modest cytotoxicity toward the human tumor cell line T24, with an IC50 value of 18.2 µM.
| Reference Key |
zhao2018moleculessporulosol,
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|---|---|
| Authors | ;Chen Zhao;Peinan Fu;Yang Zhang;Xingzhong Liu;Fengxia Ren;Yongsheng Che |
| Journal | Journal of ethnopharmacology |
| Year | 2018 |
| DOI |
10.3390/molecules23061263
|
| URL | |
| Keywords | Keywords not found |
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