characterizing spatial tuning functions of neurons in the auditory cortex of young and aged monkeys: a new perspective on old data.
Clicks: 275
ID: 180494
2013
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Popular Article
30.0
/100
275 views
62 readers
AI Quality Assessment
Not analyzed
Readership in this journal
PopularRanked #137 of 234 articles by views in Frontiers in chemistry
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 234 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Age-related hearing deficits are a leading cause of disability among the aged. While some forms of hearing deficits are peripheral in origin, others are centrally mediated. One such deficit is the ability to localize sounds, a critical component for segregating different acoustic objects and events, which is dependent on the auditory cortex. Recent evidence indicates that in aged animals the normal sharpening of spatial tuning between neurons in primary auditory cortex to the caudal lateral field does not occur as it does in younger animals. As a decrease in inhibition with aging is common in the ascending auditory system, it is possible that this lack of spatial tuning sharpening is due to a decrease in inhibition at different periods within the response. It is also possible that spatial tuning was decreased as a consequence of reduced inhibition at non-best locations. In this report we found that aged animals did have greater activity throughout the response period, but primarily during the onset of the response. This was most prominent at non-best directions, consistent with the hypothesis that inhibition is a primary mechanism to sharpen spatial tuning curves. We also noted that in aged animals the latency of the response was much shorter than in younger animals, consistent with a decrease in pre-onset inhibition. These results can be interpreted in the context of a failure of the timing and efficiency of feed-forward thalamo-cortical and cortico-cortical circuits in aged animals. Such a mechanism, if generalized across cortical areas, could play a major role in age-related cognitive decline.
| Reference Key |
eengle2013frontierscharacterizing
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;James eEngle;James eEngle;Gregg H Recanzone |
| Journal | Frontiers in chemistry |
| Year | 2013 |
| DOI |
10.3389/fnagi.2012.00036
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.