stemness-attenuating mir-503-3p as a paracrine factor to regulate growth of cancer stem cells
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2018
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Abstract
Cancer stem cells (CSCs) with self-renewal abilities endorse cellular heterogeneity, resulting in metastasis and recurrence. However, there are no promising therapeutics directed against CSCs. Herein, we found that miR-503-3p inhibited tumor growth via the regulation of CSC proliferation and self-renewal. miR-503-3p, isolated from human adipose stem cell- (ASC-) derived exosomes, suppressed initiation and progression of CSCs as determined by anchorage-dependent (colony formation) and anchorage-independent (tumorsphere formation) assays. The expression of pluripotency genes was significantly decreased in miR-503-3p-treated CSCs. Furthermore, xenografts, which received miR-503-3p, exhibited remarkably reduced tumor growth in vivo. Thus, miR-503-3p may function as a stemness-attenuating factor via cell-to-cell communications.
| Reference Key |
seo2018stemstemness-attenuating
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| Authors | ;Minkoo Seo;Seung Min Kim;Eun Young Woo;Ki-Cheol Han;Eun Joo Park;Seongyeol Ko;Eun wook Choi;Mihue Jang |
| Journal | journal of experimental psychology: general |
| Year | 2018 |
| DOI |
10.1155/2018/4851949
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