immune mediators in osteoarthritis: infrapatellar fat pad-infiltrating cd8+ t cells are increased in osteoarthritic patients with higher clinical radiographic grading
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2016
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Abstract
Osteoarthritis is a condition of joint failure characterized by many pathologic changes of joint-surrounding tissues. Many evidences suggest the role of both innate and adaptive immunity that interplay, resulting either in initiation or in progression of osteoarthritis. Adaptive immune cells, in particular T cells, have been demonstrated to play a role in the development of OA in animal models. However, the underlying mechanism is yet unclear. Our aim was to correlate the frequency and phenotype of tissue-infiltrating T cells in the synovial tissue and infrapatellar fat pad with radiographic grading. Our results show that CD8+ T cells are increased in osteoarthritic patients with higher radiographic grading. When peripheral blood CD8+ T cells were examined, we show that CD8+ T cells possess a significantly higher level of activation than its CD4+ T cell counterpart (P<0.0001). Our results suggest a role for CD8+ T cells and recruitment of these activated circulating peripheral blood CD8+ T cells to the knee triggering local inflammation within the knee joint.
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| Reference Key |
apinun2016internationalimmune
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|---|---|
| Authors | ;Jirun Apinun;Panjana Sengprasert;Pongsak Yuktanandana;Srihatach Ngarmukos;Aree Tanavalee;Rangsima Reantragoon |
| Journal | international journal of geophysics |
| Year | 2016 |
| DOI |
10.1155/2016/9525724
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| URL | |
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