pseudo-four component synthesis of mono- and di-benzylated-1,2,3-triazoles derived from aniline
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ID: 180357
2013
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Abstract
The pseudo-four component click synthesis of dibenzylated 1,2,3-triazoles derived from aniline is reported. The cycloaddition of sodium azide to N-(prop-2-ynyl)-benzenamine (I) in the presence of equimolar amounts of p-substituted benzyl derivatives, yields a mixture of mono- and dibenzylated 1,2,3-triazoles. When two equivalents of the benzyl derivative are added to the multicomponent reaction, the selective preparation of the dibenzylated compounds is achieved. The reactivity of the aniline N-H bond in monobenzylated 1,2,3-triazoles was tested by treatment with one equivalent of a p-substituted benzyl chloride at 40 °C, rendering the dibenzylated derivatives quantitatively.
| Reference Key |
mendoza-espinosa2013moleculespseudo-four
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|---|---|
| Authors | ;Daniel Mendoza-Espinosa;Guillermo E. Negron-Silva;Leticia Lomas-Romero;Atilano Gutierrez-Carrillo;Rosa Santillán |
| Journal | Journal of ethnopharmacology |
| Year | 2013 |
| DOI |
10.3390/molecules19010055
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