association between mutations in gyra and parc genes of acinetobacter baumannii clinical isolates and ciprofloxacin resistance

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ID: 180262
2015
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Abstract
Objective(s): We investigated the contribution of gyrA and parC mutational mechanism in decreased ciprofloxacin susceptibility of Acinetobacter baumannii isolated from burn wound infections. Materials and Methods: Ciprofloxacin susceptibility of 50 A. baumannii isolates was evaluated by disk diffusion and agar dilution methods. PCR and sequencing were performed for detection of mutation in gyrA and parC genes. Results: The 44 and 4 isolates of A. baumannii exhibited full and intermediate-resistant to ciprofloxacin, respectively. Overall, the 42 isolates with double mutations of gyrA and parC genes showed a higher level of ciprofloxacin resistance than the 3 isolates with single mutations of gyrA or parC. Conclusion: Simultaneous mutations in gyrA and parC genes are expected to play a major role in high-level fluoroquinolone resistance in A. baumannii; albeit a single mutation in DNA topoisomerase IV could occasionally be associated with intermediate-resistance to these antimicrobials.
Reference Key
ardebili2015iranianassociation Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Abdollah Ardebili;Abdolaziz Rastegar Lari;Maryam Beheshti;Elnaz Rastegar Lari
Journal PloS one
Year 2015
DOI
DOI not found
URL
http://ijbms.mums.ac.ir/pdf_4543_c18731cedf898e076c7b5be1471c6fa9.html
Keywords
burn gyra acinetobacter baumannii ciprofloxacin resistance

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