mib-1, agnor and dna distribution parameters and their prognostic value in neuroendocrine tumours of the lung

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ID: 180238
2011
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Abstract
One of the most important questions in clinical routine is to find out patients with good or worse prognosis to apply an optimal therapy scheme for each patient. In this study 58 patients with different neuroendocrine tumours of the lung were investigated. Histological sections were prepared with different stainings (MIB-1, AgNOR, Feulgen). By means of high resolution image cytometry stereological parameters were derived which are indicators for proliferation, ploidy and kinetics of the tumours. Cox regression analysis was calculated to test the significance of the parameters with regard to prognosis. The best parameter was MIB-1 which can easily be applied as a clinical standard staining and measurement.
Reference Key
jtting2011imagemib-1, Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Uta Jütting;Peter Gais;Karsten Rodenacker;Joachim Böhm;Heinz Höfler
Journal archives of toxicology
Year 2011
DOI
10.5566/ias.v19.p39-43
URL
http://www.ias-iss.org/ojs/IAS/article/view/620
Keywords
prognosis carcinoid image analysis

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