cytochrome p450 family 1 inhibitors and structure-activity relationships

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ID: 179858
2013
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Abstract
With the widespread use of O-alkoxyresorufin dealkylation assays since the 1990s, thousands of inhibitors of cytochrome P450 family 1 enzymes (P450s 1A1, 1A2, and 1B1) have been identified and studied. Generally, planar polycyclic molecules such as polycyclic aromatic hydrocarbons, stilbenoids, and flavonoids are considered to potentially be effective inhibitors of these enzymes, however, the details of the structure-activity relationships and selectivity of these inhibitors are still ambiguous. In this review, we thoroughly discuss the selectivity of many representative P450 family 1 inhibitors reported in the past 20 years through a meta-analysis.
Reference Key
liu2013moleculescytochrome Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Jiawang Liu;Jayalakshmi Sridhar;Maryam Foroozesh
Journal Journal of ethnopharmacology
Year 2013
DOI
10.3390/molecules181214470
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