angiotensin ii inhibitor facilitates epidermal wound regeneration in diabetic mice

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ID: 179634
2015
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Abstract
Tissue regeneration and wound healing are severely impaired in diabetes and are associated with poor circulation and dysfunctional blood vessels. Angiotensin II inhibitors are anti-hypertensive drugs used in clinical practice to regulate blood pressure and could affect tissue remodeling. We hypothesize that blocking angiotensin II, using Losartan, could facilitate tissue regeneration in diabetic mice. To this end, we established an experimental model of wound healing in streptozotocin-induced diabetic mice. Our data demonstrated that Losartan accelerates wound repair and normalizes wound stromal responses, having a beneficial role in diabetic wounds. Our findings highlight a potential therapeutic use of Losartan in improving wound repair in diabetic conditions.
Reference Key
ekamber2015frontiersangiotensin Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Maria eKamber;Maria eKamber;Vasilis ePapalazarou;Georgia eRouni;Evagelia ePapageorgopoulou;Apostolos ePapalois;Vassiliki eKostourou
Journal Journal of clinical and experimental dentistry
Year 2015
DOI
10.3389/fphys.2015.00170
URL
http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00170/full
Keywords
wound healing angiotensin ii angiogenesis

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