resistência à mefloquina do tipo riii em crianças com malária falciparum em manaus, am, brasil riii mefloquine resistance in children with falciparum malaria in manaus, am, brazil

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2000
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Abstract
Relata-se a ocorrência de resistência à mefloquina administrada na dose de 20mg/kg em 51 crianças com malária falciparum atendidas em centro de referência em Manaus, Brasil, no período de outubro a novembro de 1997. Todas as crianças foram avaliadas nos dias 3, 5, 7, 14, 21, 28 e 35 do tratamento, segundo critérios clínico e parasitológico. Foi encontrada uma incidência de resistência RIII de 5,9% (IC 95% variando de 1,5 a 17,2), a razão cura/resistência calculada foi 20:1 e cura/gravidade 62:1. Os dados chamam a atenção para a importância da resistência à mefloquina nesse grupo de crianças.
We report the occurrence of resistance to mefloquine 20mg/day in 51 children with falciparum malaria treated, at reference center of Manaus, Brazil, from October to December 1997. All children were evaluated at day 3, 5, 7, 14, 21, 28 and 35 of treatment. Clinical and parasitological cure criteria were adopted. The incidence of RIII mefloquine resistance was 5.9% (IC 95% 1.5-17.2). The cure/resistance proportion was 20:1 and cure/severity was 62:1. These findings suggest the importance of mefloquine resistance within this group of children.
Reference Key
noronha2000revistaresistncia Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Elza Noronha;Maria das Graças Alecrim;Gustavo Adolfo Sierra Romero;Vanize Macêdo
Journal mobile information systems
Year 2000
DOI
10.1590/S0037-86822000000200008
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822000000200008
Keywords
resistance malaria mefloquine p tropical medicine

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