3-(4-fluorophenyl)-<em>n</em>-[4-(4-furan-2-yl-1-oxo-2,3,7-triazaspiro[4.5]dec-3-en-2-yl)phenyl]propionamide hydrochloride
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ID: 179384
2012
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Abstract
A simple and novel route for the synthesis of new spirocyclic propionamide derivative is developed. The present work involves <em>N</em>-arylation of pyrazolone (<strong>1</strong>) using copper(I) iodide catalyst followed by reduction to give amine (<strong>2</strong>). The coupling of <strong>2</strong> with 3-(4-fluorophenyl)propionic acid and deprotection of Boc group yields the title compound (<strong>3</strong>).
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narayana2012molbank3-(4-fluorophenyl)-<em>n</em>-[4-(4-furan-2-yl-1-oxo-2,3,7-triazaspiro[4.5]dec-3-en-2-yl)phenyl]propionamide
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| Authors | ;Badiadka Narayana;Balladka Kunhanna Sarojini;Seranthimata Samshuddin;Rajagopalan Srinivasan |
| Journal | journal of chemical sciences |
| Year | 2012 |
| DOI |
10.3390/M771
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| URL | |
| Keywords |
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