validação de método espectrofotométrico na região do uv para quantificação de famotidina em cápsulas validation of an uv spectrophotometric method for quantification of famotidine in capsules

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ID: 179236
2010
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Abstract
This work describes the validation of a method for quantification of famotidine in capsules by UV spectrophotometry using as solvents buffer solution at pH 2.5 and buffer solution at pH 4.5. The results show that the method is practical, selective, accurate, precise and linear from 10.0 to 25.0 µg/mL of famotidine in both solvents. However, a variance analysis showed a lower mean percentage of famotidine when buffer at pH 2.5 is used. This effect was attributed to the instability of famotidine in acidic media. Therefore, the use of pH 4.5 buffer was considered suitable for analysis of famotidine in capsules.
Reference Key
favoretto2010qumicavalidao Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Lívia Botacini Favoretto;Juliana Maria Oliveira Souza;Rudy Bonfilio;Roberta de Cássia Pimentel Azevedo;Magali Benjamim de Araújo
Journal greece and rome
Year 2010
DOI
10.1590/S0100-40422010000700028
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000700028
Keywords
validation uv spectrophotometrychemistry

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