self-assembled nanoparticles of glycyrrhetic acid-modified pullulan as a novel carrier of curcumin
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ID: 179203
2014
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Abstract
Glycyrrhetic acid (GA)-modified pullulan nanoparticles (GAP NPs) were synthesized as a novel carrier of curcumin (CUR) with a degree of substitution (DS) of GA moieties within the range of 1.2–6.2 groups per hundred glucose units. In the present study, we investigated the physicochemical characteristics, release behavior, in vitro cytotoxicity and cellular uptake of the particles. Self-assembled GAP NPs with spherical shapes could readily improve the water solubility and stability of CUR. The CUR release was sustained and pH-dependent. The cellular uptake of CUR-GAP NPs was confirmed by green fluorescence in the cells. An MTT study showed CUR-GAP NPs with higher cytotoxicity in HepG2 cells than free CUR, but GAP NPs had no significant cytotoxicity. GAP is thus an excellent carrier for the solubilization, stabilization, and controlled delivery of CUR.
| Reference Key |
yuan2014moleculesself-assembled
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|---|---|
| Authors | ;Roufen Yuan;Fuchun Zheng;Shuping Zhong;Xiaojun Tao;Yanmei Zhang;Fenfei Gao;Fen Yao;Jiaxiong Chen;Yicun Chen;Ganggang Shi |
| Journal | Journal of ethnopharmacology |
| Year | 2014 |
| DOI |
10.3390/molecules190913305
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