rapid identification of coumarins from micromelum falcatum by uplc-hrms/ms and targeted isolation of three new derivatives

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ID: 178800
2014
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Abstract
Micromelum falcatum, a medicinal plant of the Rutaceae family, has been used in the Traditional Chinese Medicine (TCM) mainly against colds and rheumatoid arthritis. Despite its traditional use the association of its constituents with possible anti-inflammatory activity has not been explored. During this study, a rapid UPLC-ESI(+)-HRMS method was developed for the profiling of M. falcatum leave extracts and the targeted isolation of coumarin constituents. Based on chromatographic, spectroscopic and spectrometric features several 7-oxygenated coumarin derivatives were detected. After targeted isolation, eight coumarins, among them three new natural products, namely microfalcrin, microcoumaririn and micromelosidester, were purified using semi-preparative HPLC and unambiguously identified by 1 and 2D NMR. Furthermore, important spectrometric characteristics were revealed based on the HRMS and HRMS/MS spectra of the isolated 7-oxygenated coumarins facilitating their identification in complex mixtures. Finally, the anti-inflammatory properties of the extracts and representative compounds were evaluated by measuring the inhibition of the pro-inflammatory mediator NF-κB induction and nitric oxide (NO) production.
Reference Key
kouloura2014moleculesrapid Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Eirini Kouloura;Eirini Danika;Sothea Kim;Mélanie Hoerlé;Muriel Cuendet;Maria Halabalaki;Leandros A. Skaltsounis
Journal Journal of ethnopharmacology
Year 2014
DOI
10.3390/molecules190915042
URL
http://www.mdpi.com/1420-3049/19/9/15042
Keywords
lc-ms anti-inflammatory activity nf-κb rutaceae

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