a new and efficient method for the synthesis of novel 3-acetyl coumarins oxadiazoles derivatives with expected biological activity

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ID: 178784
2014
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Abstract
This paper presents the design of some novel 3-acetylcoumarin derivatives, based on minimal inhibitory concentration values (MICs) previously obtained against some microorganism cultures, Gram positive and negative bacteria and fungi. Some of these molecules exhibited antibacterial activity against S. aureus, comparable to that of the standard used (impinem). The in vitro antioxidant activities of the novel 3-acetylcoumarin oxadiazoles were assayed by the quantitative 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity method. The compounds 5c,d proved to be the most active, showing the highest capacity to deplete the DPPH radicals. Structure elucidation of the products has been accomplished on the basis of IR, 1H-NMR, 13C-NMR, NOESY and HMBC NMR data.
Reference Key
al-ayed2014moleculesa Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Abdullah Sulaiman Al-Ayed;Naceur Hamdi
Journal Journal of ethnopharmacology
Year 2014
DOI
10.3390/molecules19010911
URL
http://www.mdpi.com/1420-3049/19/1/911
Keywords
antibacterial antifungal radical scavenging activity

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