estudo comparativo das inclusões do alastrim e da vacina no macaco (macacus rhesus) a comparison of the inclusion bodies of alastrim and vaccinia in the monkey (macacus rhesus)
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1934
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Abstract
Vesiculas e pustulas contendo numerosas inclusões citoplasmicas nas celulas epidermicas, foram regularmente produzidas no macaco (Macacus rhesus), quer com o virus do alastrim, quer com o da vacina, após inoculação endovenosa e sem previa escarificação. O virus do alastrim parece menos virulento para essa especie de macaco que o da vacina. Ao passo que 12 macacos rhesus injetados por via endovenosa com sete amostras diferentes de virus do alastrim, após apresentarem com regularidade um infecção experimental, sobreviveram e se conservaram em boa saúde, a injecção endovenosa do virus da vacina recentemente preparado (polpa bruta) produziu a morte em 2, dentre 4 animais experimentados. 2. - Foram notadas diferenças pequenas, mas nitidas, na morfologia das inclusões do alastrim e da vacina, em material fixado no liquido de Helly, incluido em parafina e corado pela hematoxilina-eosina. Dizem elas respeito ao numero de inclusões encontradas em cada celula epidermica e às suas reações de coloração. 3. - As inclusões do alastrim, quando apresentam grandes dimensões, conservam-se unicas ou solitarias no citoplasma das celulas epidermicas do macaco rhesus, e coram-se em tonalidade que varia do azul escuro ao cinzento-azulado. Comtudo, em celulas que sofreram necrose, ou naquelas contendo 2 a 4 inclusões de pequenas dimensões, por vezes elas se mostram coradas em roseo. 4. - As inclusões da vacina, quando em faze adeantada de desenvolvimento, são multiplas nas celulas epidermicas do macaco rhesus e mostram, regularmente, uma policromatofilia caracteristica.
1. - Vesicles and pustules containing numerous cytoplasmic inclusion bodies within the epidermal cells were regularly produced in monkeys (Macacus rhesus) by intravenous inoculation either of alastrim virus or of recently prepared vaccine emulsion, no previous scarifications being required. Alastrim virus seems less virulent for this species of monkey than the virus of vaccinia is. While 12 rhesus monkeys injected intravenously with seven strains of alastrim virus developed regularly an experimental infection and finally recovered and remained well, the intravenous injection of vaccine virus was followed by death in two from four rhesus monkeys injected. 2. Slight but definite and regular differences were noticed between alastrim and vaccine bodies after fixation in Helly's fluid, embedding in paraffin and staining with alum hematoxylin and eosin. They are related to the number of inclusions within the cell and to their staining. 3. - In each cell of the epidermis of Macacus rhesus there is usually a single alastrim body when late stages are considered, and quite a few (2-4) when early stages are observed. Alastrim bodies stain a deep blue to grayish-blue. Nevertheless, in necrotic epidermal cells or in cells provided with a few small inclusions they sometimes present a pink staining. 4. - Vaccine bodies in late stages of development are numerous in each epidermal cell of the rhesus monkey and present regularly a characteristic polychromatophilia.
1. - Vesicles and pustules containing numerous cytoplasmic inclusion bodies within the epidermal cells were regularly produced in monkeys (Macacus rhesus) by intravenous inoculation either of alastrim virus or of recently prepared vaccine emulsion, no previous scarifications being required. Alastrim virus seems less virulent for this species of monkey than the virus of vaccinia is. While 12 rhesus monkeys injected intravenously with seven strains of alastrim virus developed regularly an experimental infection and finally recovered and remained well, the intravenous injection of vaccine virus was followed by death in two from four rhesus monkeys injected. 2. Slight but definite and regular differences were noticed between alastrim and vaccine bodies after fixation in Helly's fluid, embedding in paraffin and staining with alum hematoxylin and eosin. They are related to the number of inclusions within the cell and to their staining. 3. - In each cell of the epidermis of Macacus rhesus there is usually a single alastrim body when late stages are considered, and quite a few (2-4) when early stages are observed. Alastrim bodies stain a deep blue to grayish-blue. Nevertheless, in necrotic epidermal cells or in cells provided with a few small inclusions they sometimes present a pink staining. 4. - Vaccine bodies in late stages of development are numerous in each epidermal cell of the rhesus monkey and present regularly a characteristic polychromatophilia.
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| Authors | ;C. Magarinos Torres;J. de Castro Teixeira |
| Journal | kurdistan journal of applied research |
| Year | 1934 |
| DOI |
10.1590/S0074-02761934000100006
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