generation of induced pluripotent stem cell (ipsc) line from charcot-marie-tooth disease patient with mpz mutation (cmt1b)

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ID: 178044
2017
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Abstract
Charcot-Marie-Tooth disease (CMT1B) is an inherited neurological disorder caused by mutation of the myelin protein zero (MPZ) gene. We generated an induced pluripotent stem cell (iPSC) line from an 81-year-old patient with CMT1B by electroporating of lymphoblastoid cell lines with episomal plasmids encoding OCT4, SOX2, KLF4, L-MYC, LIN28, and p53-targeting shRNA. The established iPSCs expressed various pluripotency markers, demonstrated the potential to differentiate into cells of the three germ layers in vitro, had a normal karyotype and retained the MPZ mutation.
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son2017stemgeneration Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Daryeon Son, Phil Jun Kang, Wonjin Yun, Seungkwon You
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Journal journal of energy chemistry
Year 2017
DOI
10.1016/j.scr.2017.08.002
URL
http://www.sciencedirect.com/science/article/pii/S1873506117301575
Keywords
Biology (General)

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