tree-based methods for discovery of association between flow cytometry data and clinical endpoints

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ID: 177992
2009
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Abstract
We demonstrate the application and comparative interpretations of three tree-based algorithms for the analysis of data arising from flow cytometry: classification and regression trees (CARTs), random forests (RFs), and logic regression (LR). Specifically, we consider the question of what best predicts CD4 T-cell recovery in HIV-1 infected persons starting antiretroviral therapy with CD4 count between 200 and 350 cell/μL. A comparison to a more standard contingency table analysis is provided. While contingency table analysis and RFs provide information on the importance of each potential predictor variable, CART and LR offer additional insight into the combinations of variables that together are predictive of the outcome. In all cases considered, baseline CD3-DR-CD56+CD16+ emerges as an important predictor variable, while the tree-based approaches identify additional variables as potentially informative. Application of tree-based methods to our data suggests that a combination of baseline immune activation states, with emphasis on CD8 T-cell activation, may be a better predictor than any single T-cell/innate cell subset analyzed. Taken together, we show that tree-based methods can be successfully applied to flow cytometry data to better inform and discover associations that may not emerge in the context of a univariate analysis.
Reference Key
eliot2009advancestree-based Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;M. Eliot;L. Azzoni;C. Firnhaber;W. Stevens;D. K. Glencross;I. Sanne;L. J. Montaner;A. S. Foulkes
Journal journal of hepatocellular carcinoma
Year 2009
DOI
10.1155/2009/235320
URL
http://dx.doi.org/10.1155/2009/235320
Keywords
biology (general)statistics

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