Transient postnatal overfeeding causes liver stress-induced premature senescence in adult mice

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ID: 17762
2017
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Abstract
Abstract Unbalanced nutrition early in life is increasingly recognized as an important factor in the development of chronic, non-communicable diseases at adulthood, including metabolic diseases. We aimed to determine whether transient postnatal overfeeding (OF) leads to liver stress-induced premature senescence (SIPS) of hepatocytes in association with liver structure and hepatic function alterations. Litters sizes of male C57BL/6 mice were adjusted to 9 pups (normal feeding, NF) or reduced to 3 pups during the lactation period to induce transient postnatal OF. Compared to the NF group, seven-month-old adult mice transiently overfed during the postnatal period were overweight and developed glucose intolerance and insulin resistance. Their livers showed microsteatosis and fibrosis, while hepatic insulin signaling and glucose transporter protein expressions were altered. Increased hepatic oxidative stress (OS) was observed, with increased superoxide anion production, glucose-6-phosphate dehydrogenase protein expression, oxidative DNA damage and decreased levels of antioxidant defense markers, such as superoxide dismutase and catalase proteins. Hepatocyte senescence was characterized by increased p21WAF, p53, Acp53, p16INK4a and decreased pRb/Rb and Sirtuin-1 (SIRT-1) protein expression levels. Transient postnatal OF induces liver OS at adulthood, associated with hepatocyte SIPS and alterations in liver structure and hepatic functions, which could be mediated by a SIRT-1 deficiency.
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yzydorczyk2017transientscientific Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Yzydorczyk, Catherine;Li, Na;Chehade, Hassib;Mosig, Dolores;Bidho, Mickael;Keshavjee, Basile;Armengaud, Jean Baptiste;Nardou, Katya;Siddeek, Benazir;Benahmed, Mohamed;Vergely, Catherine;Simeoni, Umberto;
Journal Scientific reports
Year 2017
DOI
DOI not found
URL
http://link.springer.com/article/10.1038/s41598-017-11756-2
Keywords Keywords not found

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