susceptibilidade da mucosa gástrica à ação lesiva de um sal biliar em ratos chagásicos crônicos
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ID: 177434
1987
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Abstract
Ratos inoculados previamente com a cepa Y do Trypanosoma cruzi (n = 15) e ratos-controles de mesma idade e sexo (n = 15) foram submetidos a estudo que consistiu no exame da mucosa gástrica após a exposição in vivo da mesma à solução acidificada de um sal biliar, o taurocolato de sódio (TC). Em 10 animais de cada grupo procedeu-se também à contagem dos neurônios do plexo mientérico do estômago e ao exame histopatológico dos corpos neuronais, feito em microscopia óptica convencional. Escores indicativos da gravidade das lesões produzidas pelo TC foram significativamente maiores (P < 0,002) nos ratos chagásicos que nos controles. A área erosada da mucosa gástrica, em % da área total da região glandular do estômago, foi significativamente maior (P0,10) entre os ratos chagásicos (1683,6 ± 449,7 n = 10) e os controles (1732,8 ± 401,1 n = 10). Não houve diferença qualitativa ao exame histopatológico dos corpos neuronais. Estes resultados indicam que, na doença de Chagas experimental crônica, a mucosa gástrica é mais sensível à ação lesiva do TC, o que sugere redução da citoproteção natural do estômago. Esta anormalidade não deve decorrer de alterações da inervação intrínseca que impliquem redução do número de neurônios intramurais do estômago, mas pode ser o resultado de alterações qualitativas não detectáveis à microscopia óptica.
Rats inoculated with the Ystrain of Trypanosoma cruzi and control rats of the same age and sex were submitted to examination of the gastric mucosa exposed in vivo to an acidified solution of a bile salt, sodium taurocholate (TC). Neuronal counts in the myenteric plexus of the stomach were also performed for several animals in both groups. The scores indicating the severity of the lesions produced by TC were significantly higher (P < 0.002) in chagasic(n - 15) than in control rats (n = 15). The eroded area of the gastric mucosa, expressed as a percentage of the total area of the glandular region of the stomaçh, was significantly larger (P < 0.02) in the chagasic (25.2 ±18.0) than in control (11.0 + 17.4) rats. As to the number of intramural ganglion cells in the stomach, no significant difference (P > 0.10) was observed between chagasic (1683.6 ± 449.7, n = 10) and control (1732.8 ± 401.1, n = 10) animals. These results indicate that in experimental chronic Chagas' disease the gastric mucosa is more sensitive to the damaging action of TC, suggesting reduction of the natural cytoprotection of the stomach. This abnormality does not appear to be due to changes in intrinsic innervation that may imply a reduction of the number of intramural neurons of the stomach.
Rats inoculated with the Ystrain of Trypanosoma cruzi and control rats of the same age and sex were submitted to examination of the gastric mucosa exposed in vivo to an acidified solution of a bile salt, sodium taurocholate (TC). Neuronal counts in the myenteric plexus of the stomach were also performed for several animals in both groups. The scores indicating the severity of the lesions produced by TC were significantly higher (P < 0.002) in chagasic(n - 15) than in control rats (n = 15). The eroded area of the gastric mucosa, expressed as a percentage of the total area of the glandular region of the stomaçh, was significantly larger (P < 0.02) in the chagasic (25.2 ±18.0) than in control (11.0 + 17.4) rats. As to the number of intramural ganglion cells in the stomach, no significant difference (P > 0.10) was observed between chagasic (1683.6 ± 449.7, n = 10) and control (1732.8 ± 401.1, n = 10) animals. These results indicate that in experimental chronic Chagas' disease the gastric mucosa is more sensitive to the damaging action of TC, suggesting reduction of the natural cytoprotection of the stomach. This abnormality does not appear to be due to changes in intrinsic innervation that may imply a reduction of the number of intramural neurons of the stomach.
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| Authors | ;Luiz Ernesto de Almeida Troncon;Osman Caiixto Silva;Sergio Zucoloto;Francisco Ferriolli Filho;Ulysses Garzella Meneghelli |
| Journal | mobile information systems |
| Year | 1987 |
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