use of labelled cisplatin obtained by direct irradiation in a preliminary biodistribution study

Clicks: 224
ID: 177385
2005
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Abstract
This work presents the preparation of radiolabelled cis-dichlorodiammineplatinum (II), CDDP*, from its direct irradiation into a cadmium capsule, using the TRIGA MARK I IPR R-1 research reactor of the CDTN. The ability to detect CDDP* in Ehrlich tumour-bearing mice after administration via an intravenous route was evaluated. After 24 hours, blood and some organs were collected to determine the incorporated activity. The CDDP* showed a great chemical purity and high specific activity that resulted in an optimum in vivo detection. The CDDP* was taken up principally by liver, spleen and kidney. The CDDP* obtained from this condition was shown to be a good tool for biodistribution studies.
O presente trabalho refere-se à obtenção de cis-diclorodiaminoplatina (II) radiomarcada, CDDP*, a partir de sua irradiação direta numa cápsula de cádmio. A irradiação foi realizada no reator de pesquisa TRIGA MARK I IPR R-1. Em seguida, foi avaliada a capacidade de detecção da radioatividade emitida por CDDP* após sua administração intravenosa em camundongos acometidos por tumor de Ehrlich. Após 24 horas, fez-se a coleta de amostras de sangue e de alguns órgãos, a fim de se avaliar o nível de radioatividade presente nos mesmos. A CDDP* obtida apresentou uma ótima pureza química e elevada atividade específica que permitiu um excelente nível de detecção. A CDDP* foi captada principalmente pelo fígado, baço e rins. Portanto, a CDDP* obtida na condição de bombardeamento supracitada mostrou ser uma ferramenta útil para a realização de estudos de biodistribuição.
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jnior2005brazilianuse Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Álvaro Dutra de Carvalho Júnior;Fabiana Moreira Abrantes;Maria Ângela Menezes;Alexandre Soares Leal;Valbert Nascimento Cardoso;Mônica Cristina de Oliveira
Journal current drug delivery
Year 2005
DOI
10.1590/S1516-89132005000700013
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700013
Keywords
biodistribution triga research reactorbiotechnology

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