the cyp2b6 g516t polymorphism influences cd4+ t-cell counts in hiv-positive patients receiving antiretroviral therapy in an ethnically diverse region of the amazon
Clicks: 250
ID: 177278
2017
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Emerging Content
30.0
/100
250 views
37 readers
AI Quality Assessment
Not analyzed
Readership in this journal
EmergingRanked #67 of 169 articles by views in israel journal of chemistry
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 169 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Objectives: Cytochrome P450 (CYP) enzyme polymorphisms seem to significantly influence the variability of the responses to certain antiretroviral drugs and their toxicity levels. The objective of this study was to evaluate the influence of the CYP2B6 G516T polymorphism on hepatic, renal, immunological, and viral marker changes in HIV-1-positive patients receiving treatment in an ethnically diverse region of the Amazon.
Methods: CYP2B6 G516T genotyping was performed by real-time PCR (RT-PCR) in samples from 185 patients. Urea, creatinine, aspartate aminotransferase (AST), alanine aminotransferase (ALT), CD4+/CD8+ T-cell counts, and HIV-1 plasma viral load were measured.
Results: The polymorphic CYP2B6 G516T allele frequency was 0.36, which is different from the frequencies in other ethnic groups. The polymorphic genotype was associated with changes in the urea and ALT levels, although the median values were within the normal range. The TT genotype was also associated with significantly lower CD4+ T-cell counts in patients using efavirenz.
Conclusions: The CYP2B6 G516T polymorphism seems to affect the response to efavirenz treatment by reducing CD4+ T-cell counts in patients with a high degree of miscegenation who use this antiretroviral agent.
| Reference Key |
queiroz2017internationalthe
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;Maria Alice Freitas Queiroz;Rogério Valois Laurentino;Ednelza da Silva Graça Amoras;Mauro Sérgio Moura de Araújo;Samara Tatielle Monteiro Gomes;Sandra Souza Lima;Antonio Carlos Rosário Vallinoto;Marluísa de Oliveira Guimarães Ishak;Ricardo Ishak;Luiz Fernando Almeida Machado |
| Journal | israel journal of chemistry |
| Year | 2017 |
| DOI |
10.1016/j.ijid.2016.12.002
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.