alkaline phosphatase flare phenomenon following epidermal growth factor receptor-tyrosine kinase inhibitor treatment of non-small cell lung cancer: report of a case and case review

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ID: 176868
2014
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Abstract
Alkaline phosphatase (ALP) flare phenomenon documented as scintigraphic flare phenomenon due to elevated serum ALP levels produced by osteoblasts reflects an osteoblastic reaction in response to the effective therapy of non-small cell lung cancer (NSCLC). Here, we report a case of ALP flare following gefitinib treatment for NSCLC. We also retrospectively analyzed the prevalence of ALP flare in lung cancer patients treated via epidermal growth factor receptor-tyrosine kinase inhibitor in our hospital. Recognition of this phenomenon is important for physicians treating NSCLC patients to avoid discontinuation of a potentially beneficial treatment because of misdiagnosis for refractory multiple bone metastasis or adverse effect.
Reference Key
yasuda2014respiratoryalkaline Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Yuko Yasuda;Kodai Kawamura;Kazuya Ichikado;Masakazu Yoshioka
Journal current treatment options in cardiovascular medicine
Year 2014
DOI
10.1016/j.rmcr.2014.09.003
URL
http://www.sciencedirect.com/science/article/pii/S2213007114000409
Keywords
non-small cell lung cancer alkaline phosphatase

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